Skrees were part of the army that was laying siege to the Palace of Power when Kevin Keene arrived in Videoland. When Princess Lana got kidnapped by Mother Brain, she found herself in the underground corridors of Metroid with Kevin and Duke when they came to rescue her. They were immediately attacked by four Skrees, one of which Kevin blasted with his Zapper as they fled from the other three. They were attacked by one more Skree after escaping the Multiviola, which Kevin blasted as it flew toward them.
Kevin was also attacked by a Skree after being tricked by Mother Brain and imprisoned on Metroid. He was able to destroy it by throwing an orb he found in a statue's mouth.