Samus Aran is a character in the comic book continuity of Captain N: The Game Master. She is based on the video game character of the same name.
Cartoon
Samus Aran doesn't appear in the cartoon series.
Comic
Samus Aran is a beautiful bounty hunter from Videoland. Her primary adversary is Mother Brain. She uses a starship called Hunter IV to travel between worlds and competes with Princess Lana for Kevin's affections.
Samus was likely written into the comic to fill the gap left by the various third-party characters who didn't appear. She never appeared in the show because Jeffrey Scott "never heard of her," despite her archenemy being the show's main villain.