Samus Aran doesn't appear in the cartoon series.
Samus Aran is a beautiful bounty hunter from Videoland. Her primary adversary is Mother Brain. She uses a starship called Hunter IV to travel between worlds and competes with Princess Lana for Kevin's affections.
Samus was likely written into the comic to fill the gap left by the various third-party characters who didn't appear. She never appeared in the show because Jeffrey Scott "never heard of her," despite her archenemy being the show's main villain.